There have been reports of depression, psychosis, suicide attempts, and suicide, in people taking isotretinoin. Exactly how or why this happens isn’t known, but some researchers believe the drug may disrupt the way serotonin is made and used by the body.
Don’t let this possible side effect scare you too much. Most people who take isotretinoin never experience any psychiatric problems, and some research in dermatology has questioned if there’s really any link at all. Just as a precaution, though, make sure you tell your doctor if you have a history of depression, or mental illness. Know the warning signs and tell your doctor immediately if you experience any symptoms of depression, psychosis, or if you are having suicidal thoughts. More »